The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice. Department of Biology, University of Rochester Research Methodologies Host/microbe relationships andcontrol of intestinal stem cell behavior in homeostasis and disease -, Signal transduction growth factor receptors; protein structure; drug design and chemical biology; signaling cues that direct cell proliferation, differentiation and development -, Etiology of spontaneous birth defects in mammals; mechanisms of meiotic recombination; DNA repair proteins in meiosis and recombination; germ cell development; ovarian development -, Pharmacology; cancer cell biology; small GTPase regulation of intracellular traffic and cellular growth control -, Reproductive physiology; molecular and cellular physiology; epigenetic reprogramming during the egg-to-embryo transition; mechanisms by which specific histone modifications are dynamically regulated during hormone-dependent gene transcription in breast cancer cells, Metalloenzyme structure and catalysis; protein electron transfer; nitric oxide enzymology; bacterial chemotaxis; circadian clock photo sensors -, Medical geneticsand genomics andcancer biology research, Molecular biotechnology; protein biogenesis and folding pathways; protein engineering -, Mechanisms of infectious diseases with particular emphasis on molecular mechanisms of bacterial infections in animal models of human diseases; host-pathogen relationships, hereditary diseases in dogs to identify genetic variants contributing to disease development -, Tissue-engineered model systems for analysis of microenvironmental conditions fundamental to cancer pathogenesis and therapy -, My research interests include creating systems to evaluate and improve the welfare of research animals, and the development and refinement of animal models of human disease, (a) Immunology of nanomaterials and implantable materials and (b) safe and targeted delivery of mRNAs and DNAs for cancer immunotherapies/vaccines andneurological diseases, Tissue morphogenesis; cell shape and architecture; organ development; gut morphogenesis; mammary gland biology; breast cancer -, Cellular biomechanics; mechanotransduction;cell migration; muscular dystrophy and cancer cell biology -, The laboratory is currently focused on further advancing the novel 3D organ-on-chip systems, as well as developing both cellular and molecular tools and in vivo models, to better understand the mechanisms through which cells regulate their response to biological and mechanical cues -, Understanding innate immunity from the receptors that detect microbes to how innate immune cells react to changes in their environment during inflammatory processes -, Regulation of cell signaling by protein lipidation, Use of contemporary methods to explore lymphocyte function in spontaneous veterinary disease, Stem cells and cancer; pathogenesis of ovarian and prostate cancers; modeling of human disease in genetically modified mice and human organoids -, Ion channel receptor/ligand interactions; NMR and molecular dynamics; molecular neurobiology and biophysics; neurotransmitter receptors and signal transduction, membrane protein traffickingandquality control mechanisms -, Role of cellular protein, lipids, and glycans play in viral infection, Genetics of reproduction and germ cell development; cancer genetics; meiosis; DNA repair; genome manipulation in mice; functional genomics -, Signaling of cellular oxidative stress; molecular mechanisms used by cellular pathways that sense and signal redox imbalances within the cell, Cell signaling and genome maintenance; DNA replication stress; phosphproteomics, Hematopoietic and hemostatic disorders in animals; mechanisms of cancer metastasis -, Basic cellular and molecular mechanisms implicated in cell fate choice and stem cell activity within tissues -, Veterinary viral pathogenesis; mesenchymal stem cell biology and regenerative medicine; mammary stem cell biology and carcinogenesis -, Molecular mechanisms for the maintenance of genomic stability; cellular responses to DNA damage; mouse models of human cancer -, Cancer biology; stem cell biology; biochemistry and cell biology -, Leukemia; cell growth and differentiation; oncogenes/genetics -.

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